EGRAC Test: Meaning, Normal Range, and Vitamin B2 Deficiency
The EGRAC test (glutathione reductase activity coefficient) measures functional vitamin B2 status in red blood cells. The normal range is 1.00–1.20. High EGRAC levels indicate vitamin B2 deficiency, while low values are rare and usually linked to supplementation. This blood test detects deficiency earlier than direct riboflavin measurements.
Contents
Result interpretation EGRAC
What your result means based on common reference ranges
EGRAC levels within 1.00–1.20 indicate adequate vitamin B2 status and normal antioxidant enzyme function.
Slightly elevated EGRAC levels suggest early vitamin deficiency affecting red blood cell metabolism and oxidative stress balance.
High EGRAC levels above 1.40 confirm vitamin B2 deficiency and impaired glutathione recycling with anemia risk.
Low EGRAC levels are uncommon and may reflect excessive supplementation or altered enzyme kinetics in genetic conditions.
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What is EGRAC?
The EGRAC blood test assesses how effectively glutathione reductase works inside red blood cells, reflecting vitamin B2 availability. This enzyme depends on FAD (flavin adenine dinucleotide), a riboflavin-derived cofactor essential for antioxidant defense and cellular metabolism. Unlike plasma riboflavin tests, EGRAC evaluates intracellular function, making it more sensitive to early deficiency. Elevated levels are associated with oxidative stress, anemia, and impaired folate metabolism. It is commonly used alongside markers like homocysteine and urinary riboflavin to understand long-term nutritional status and metabolic balance.
Reference ranges
Causes of abnormal values
Causes of low EGRAC
- • High-dose vitamin B2 supplementation — enzyme saturation effect
- • G6PD deficiency — altered baseline enzyme activity
- • Excess intracellular FAD — reduced response to added riboflavin
Causes of high EGRAC
- • Low dietary riboflavin intake — insufficient cofactor for enzyme activation
- • Chronic alcohol use — reduced intestinal absorption and metabolic utilization
- • Hypothyroidism — impaired conversion to active FAD form
- • Malabsorption disorders — reduced vitamin uptake in gut
- • Phototherapy in newborns — accelerated riboflavin degradation
- • Medication interference — drugs inhibit riboflavin-dependent enzymes
EGRAC in combination with other markers
Possible symptoms
- •Cracks at mouth corners (cheilosis)
- •Inflamed or magenta-colored tongue (glossitis)
- •Light sensitivity and eye irritation
- •Seborrheic dermatitis (oily skin rash)
- •Persistent sore throat
When to see a doctor
Consult a doctor if EGRAC levels exceed 1.40 or continue rising over time. Medical advice is also needed if symptoms like cheilosis or photophobia persist despite dietary changes.
What to do if abnormal
- Increase riboflavin-rich foods (liver, eggs, dairy)
- Reduce alcohol intake to improve absorption
- Check thyroid function if abnormalities suspected
- Store supplements away from light exposure
- Use vitamin B2 supplements under medical guidance
The information on this page is intended for general understanding of test results and does not replace medical consultation. Accurate interpretation requires considering other blood markers and individual factors.
Content is based on medical literature and used within the PulseBook analytical system.
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